Born August 4, 1901, though he purported to be born July 4, 1900, Lewis Armstrong, as he was known by in his youth, lived the first five years of his life on Jane Alley in the care of his paternal grandmother, Josephine Armstrong.
In his autobiography, Satchmo: My Life in New Orleans, Armstrong described the neighborhood:
"...more people were crowded than you ever saw in your life. There were church people, gamblers, hustlers, cheap pimps, thieves, prostitutes and lots of children. There were bars, honky-tonks, and saloons..."
In order to support the family, Armstrong's grandmother took in washing and ironing. When not attending school, Armstrong would help deliver clothes to her customers.  The two attended Sunday services regularly, where Armstrong developed his singing skills. In his autobiography, Armstrong recalled that "at church my heart went into ever hymn I sang."
At the age of five, Armstrong left his grandmother's home on Jane Alley to live with his mother May Ann on LIberty and Perdido Street.
In the 1960s, preservationists at the New Orleans Jazz Club attempted to save the house from demolition but failed to secure funding. The building was demolished to make way for a municipal court and police complex.